Endocrine Abstracts

Purpose: Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-I) are currently the principal biomarkers used to assess disease activity in acromegaly and any discrepancy between them renders interpretation of results inconclusive. The purpose of this study was to assess the frequency of discrepant results and identify parameters that might affect the emergence of this phenomenon.Methods: A systematic review of Medline and Scopus was performed (1987&...

Context: Weight reduction in obese patients with type 2 diabetes mellitus (T2DM) leads to hyperglycaemia improvement and reduces complications. Thus it is important to investigate the potential benefits of the use of different dietetic approaches on weight loss.Objective: To examine the efficacy of two different dieting methods on weight loss in patients with T2DM.Materials and methods: 30 participants with T2DM, 18 men and 12 wome...

Introduction: Metreleptin, a recombinant analogue of leptin, is the only drug available for the treatment of generalized or partial lipodystrophy. Familial partial lipodystrophy (FPL) is a rare genetic disorder characterized by selective loss of subcutaneous adipose tissue, ectopic fat deposition, decreased leptin levels, and varying metabolic disorders, which in some patients can be quite severe and life-threatening. We present here such a woman with FPL who is treated with m...

Introduction: Liraglutide treatment reduces cardiovascular complications in patients with diabetes mellitus (DM), which may imply a favorable impact on the endothelial function. The aim of the present study was to investigate in vitro the effect of liraglutide on endothelial redox balance and the parallel expression of CRH, UCN1, 2 and 3 neuropeptides, under normoglycemic and hyperglycemic conditions.Methods: Macroendothelial cell line EAhy926 w...

Introduction: Diabetes is characterised by increased oxidative stress and an insufficient antioxidant response, which are crucial for the initiation and progression of atherosclerosis. GLP-1 agonists, used for the treatment of diabetes, are considered as cardioprotective agents but under that concept, there are limited data on their ability to influence the endothelial antioxidant response.Methods: In order to answer this question we studied the influenc...

Introduction: Eating habits, food choices and exercise affect glycaemic control in patients with Type 1 Diabetes Mellitus (T1DM). The purpose of this study was to evaluate eating behaviors, food choices and the level of physical activity in patients with T1DM.Methods/design: A random sample of 84 patients (M/F: 31/53) with T1DM, aged 34+11.9 years, living in central Greece, were individually interviewed. Food consumption was assessed by a semi-q...

Objective: Published results of reduced morbidity and mortality with tight Glycemic Control of critical patients could not be reproduced in large prospective trials. Glycemic goals according to current respective guidelines include a target blood glucose range 140-180 mg/dl, while lower blood glucose targets may be appropriate for some patients. This study aims to provide real world evidence to this field.Methods: We performed a retrospective study using...

Introduction: Pituicytoma is a rare, primary benign, tumor of the sellar and suprasellar regions which is arising from pituicytes of the neurohypophysis and infundibulum and mainly affects middle age adults. We present here such a casePresentation: A 64-years-old man was referred to our clinic. For further investigation of a sellar lesion with suprasellar extension. The patient underwent investigations due to visual disturbances which he noticed initiall...

Objective/Design: Gestational diabetes mellitus (GDM) has been associated with serious complications for both the pregnant woman and the newborn. Vitamin B12 is implicated in some important metabolic procedures such as methylation and one carbon cycle and its deficiency can cause serious health problems, such as hyperhomocysteinemia, defective synthesis of neurotransmitters and fatty acids and more. However, it is not known if there is a link between vitamin B12 deficiency and...

Introduction: Hypophysitis is a rare entity, more common in women in pregnancy and the postpartum period and can cause various symptoms such as headache, hypopituitarism and visual disturbances. Stalk thickening and homogeneous enhancement of the gland are the characteristic magnetic resonance imaging (MRI) findings. The diagnosis is based on the clinical picture and on follow up MRIs. Usually involves the anterior pituitary alone, whereas isolated-posterior-pituitary-involvem...